Post Inflammatory Erythema (P.I.E) - All You Need To Know

Post Inflammatory Erythema (P.I.E) – All You Need To Know

Post-inflammatory erythema (P.I.E) is a relatively new term coined in 2013. P.I.E occurs when blood flow stops during the inflammation stage. Inflammation, blood vessel dilation, and any damage to those blood vessels can cause red or pink marks to appear on the skin. In addition, if your skin doesn’t heal right, you may experience a loss of collagen or extra tissue, which causes scars. P.I.E can appear as solo spots or in clusters on the skin. 

What causes P.I.E?

P.I.E occurs when there is damage to the blood vessel during the inflammation stage. A common cause of P.I.E is cystic acne, but any inflammatory skin condition such as sun damage or dermatitis can be at fault. P.I.E can be particularly frustrating as even though your battle with acne may be over, you have the residual red, flat marks to deal with. 

At Aesthetics of Liverpool, we understand how frustrating the journey to flawless skin can be. That is why we want to help you achieve that airbrushed finish you’ve been working for. Please read below for a list of our treatments and services which can help you achieve flawless skin. 

Specialist Skin Peels for P.I.E: 

The Perfect Derma Peel 

This revolutionary peel transforms your skin from dull and tired to healthier and younger within the week! The peel works by targeting the skin on a cellular level to fight oxidant damage and is the anti-ageing answer to a range of skin complaints – including P.I.E. In addition, the Perfect Derma Peel claims to be the only medical peel that contains glutathione.“Glutathione is a very potent peptide that is commonly used as a brightener and is a coenzyme that helps reduce inflammatory reactions in the cells,” says Svendsen. “Recently, it’s experienced a surge in popularity, with glutathione drips and supplements used in many forms of anti-ageing and healing therapies.” The process is swift and is suitable for all skin types. The follow up topical cream is applied three days later, and the top two layers of skin will peel away, unclogging pores and revealing brighter, even skin tones. 

The Perfect Derma Peel also contains: 

  • trichloroacetic acid (TCA)
  • salicylic acid
  • retinoic acid
  • kojic acid
  • phenol
  • vitamin C

All of which combine to reveal your skin’s former glow beneath the surface, seeing your red marks and scarring from P.I.E peel away. You can achieve similar results with our Cosmelan Peel too. 

Cosmelan Peel

The world’s number one skin peel! No wonder it’s so popular at our clinic. Say goodbye to uneven skin tones and pigmentation. This peel effectively evens and brightens out the skin, eliminating signs of imperfections. The Cosmelan Peel works to eliminate the amount of melanin in the skin – melanin is what causes the over pigmentation in the first place. In addition, it works by preventing certain enzymes such as Tyrosinase which is needed to produce melanin. As a result, Cosmelan works to create a flawless, even complexion.

Unlike other hydroquinone and tretinoin treatments, which can be harsh on the skin and cause some unpleasant side effects, a Cosmelan Peel contains Azelaic Acid, which kills bacteria on the surface of the skin and boosts new skin cell production; and Kojic Acid, which is an acid that is derived from several different types of naturally-existing fungi and which inhibits the production of melanin in the skin.

In relation to P.I.E, as our Cosmelan Peel can reduce your melanin production, any pigmentation in your skin is reduced. This means the red and pink marks on your skin, caused by your inflammation, is eradicated. And, as it will balance your skin’s natural oil production, you can go back to having a clear and pigment-free complexion.

Intense Pulsed Light (IPL)

At Aesthetics of Liverpool, we strongly recommend our LED Light Therapy to help combat P.I.E. Unlike laser treatments, IPL is able to release light in a multitude of different wavelengths. A similar way of understanding IPL is a photo flash. Where a laser’s light is focused into a single beam, IPL scatters many light rays onto your skin’s surface. Here, the light penetrates down into your dermis without damaging your epidermis on top.

Within your skin, there are pigment cells. As light wavelengths pass through your skin, these cells absorb the light’s energy, converting it into heat. It is this heat that destroys unwanted pigment. Our LED Light Therapy allows us to offer blue, green, yellow and red treatments, with the different colours addressing different conditions. To remove redness and pigmentation, we recommend yellow lights; however, in some instances, red and green can also prove beneficial. 

As we offer all our clients an initial consultation, our medical experts will be able to carry out a thorough assessment to ensure they achieve their desired results.  

Other treatments for P.I.E…

Co2 Resurfacing

Highly effective laser treatment is available at Aesthetics of Liverpool to eradicate wrinkles, acne scars and skin discolouration. With additional contouring benefits! CO2 pumps superficial energy into the skin, creating tiny white ablated dots of heat-stimulated tissue through the skin layers, creating an inflammatory response that stimulates new collagen and proteoglycan production. The treatment also removes the top layer of the epidermis, removing any pigmented skin and revealing your rejuvenated skin below.  

PRX and Micro-Needling

Yet another skin bio-revitalisation treatment that helps to remove P.I.E is our PRX-T33. When this is combined with micro-needling procedures, the results on P.I.E are incredible. Unlike traditional skin peels, the top layer of the skin does not peel away. Instead, the PRX-T33 acts as a biostimulator for your skin’s rejuvenation. 

PXR-T33 is based around the Trichloroacetic Acid (TCA) skin peel. This acidic solution is entirely harmless to your skin and normally would only allow the top layer of the epidermis to peel. However, in a PRX-T33, the TCA is mixed with hydrogen peroxide (H2O2). The addition of H2O2 means the TCA permeates into your skin, reaching the dermis below. Here it stimulates your collagen production and kick-starts a process of regeneration. By combining this peeling-free biostimulation treatment with our micro-needling treatments, you can heighten the rejuvenation part of the PXR-T33.

Micro-Needling Treatments at Aesthetics of Liverpool

Precision Lift SkinPen

Our SkinPen creates hundreds to thousands of tiny pinpricks into your skin’s dermis every second. What these ‘micro’ punctures do is stimulate your body’s natural healing process, accelerating your collagen production. Natural collagen reduces the risk of scar tissue and allows your skin to heal without pigmentation, scar or defect. So after the peel has removed your P.I.E blemishes and pigmentation, the micro-needling treatment provides your body with the boost it needs to repair and maintain a smooth complexion. 


Similarly to our SkinPen treatment, Morpheus8 is a treatment that combines the collagen-stimulating properties of micro-needling with the skin tightening benefits of Radio Frequency technology. As we know, micro-needling allows our dermis to become stimulated into producing collagen as our natural healing process is fast-track. But, when combined with Radio Frequency, the texture and tone of your healed skin are improved.


Photobiomodulation used to be known as Low-Level Laser Therapy but, here at Aesthetics of Liverpool, we refer to this treatment as LED Light Therapy. When we are exposed to red, infra-red light, our body is better at reducing inflammation, soft tissue healing and dealing with chronic pain. For those who suffer from P.I.E, this treatment becomes a lifeline in reducing the inflammation that causes their skin pigmentation and scars. Red light is able to penetrate within the skin and reduce oxidative stress while increasing ATP (adenosine triphosphate) – an organic compound that delivers energy to cells. With more ATP, cell metabolism is improved, which, in turn, reduces inflammation. 

When combined with a PXR-T33 Skin Peel, not only is the cause of your inflammation treated by the photobiomodulation, but your skin’s collagen production receives a healthy boost aiding your healing and rejuvenation process.

Vascular Laser Treatment

Vascular Laser treatment has progressed tenfold over the last decade. Laser stands for Light Amplification by the Stimulated Emission of Radiation. These lasers can target particular blood vessels under the skin whilst minimising damage to your epidermis. Through selective heating and closing off blood vessels, pulsed light helps to repair blood vessels. In the case of P.I.E, the lasers can target your dilated blood vessels, correcting the inflammation and any discolouration at its very cause. 

During a vascular laser treatment, smooth, consistent light pulses are directed into the blood vessels gently giving them energy. The energy stimulates the area and kick-starts the skin’s natural collagen and elastin production, boosting your skin’s rejuvenation leaving fresher and tighter skin. 

If you are tired of dealing with P.I.E and are interested in receiving treatment from our specialists, call us today on 0151 203 1393 to book in for your consultation to decide what treatment would work best for your unique skin type. Don’t hide behind makeup; it’s time to give your skin the extra boost it needs to restore its former glow. 

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Medical Disclaimer: The information on this site is not intended or implied to be a substitute for professional medical advice, diagnosis or treatment. All content, including text, graphics, images and information, contained on or available through this web site is for general information purposes only. *Disclaimer: Actual results may vary on an individual basis. All deposits are non-refundable. Please note that we do not treat under 21 years of age and that all bookings are subject to a consultation with our Clinical Director to ensure you are safe for treatment.  Thread Lifts are carried out by Dr Suneetha Kovvuri GMC No 5195454.

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